There are tons of 2pac "instrumentals" floating on the net when they're really loops, remakes, or reduced vocal versions so this list will filter out the fake ones.  All instrumentals here are OFFICIAL unless noted otherwise.  I included a few loops since the original tracks are basically a looped beat so there's no difference.  The ones labeled as "unofficial instrumental" are questionable as I haven't found a source for them...no single or promo can be found anywhere so they could be a remake, but they sound good enough to me.  I will continue to update this as I find them and if anyone has anything that I don't have, send it to me & I'll review it to confirm its legitimacy

2pac - Ambitionz Az A Ridah (Ambitionz Az A Fighta loop)
2pac - Breathin (instrumental)
2pac - Brenda's Got A Baby (instrumental)
2pac - Can't C Me (instrumental)
2pac - Changes (instrumental)
2pac - Crooked Nigga Too (Raphael Saadiq remix instrumental)
2pac - Dear Mama (instrumental Moe Z mix)
2pac - Dear Mama (instrumental)
2pac - Do For Love (instrumental)
2pac - Flex (instrumental)
2pac - Ghetto Gospel (instrumental)
2pac - Ghetto Star (Ant Banks remix instrumental)
2pac - God Bless The Dead (instrumental)
2pac - Hail Mary (instrumental)
2pac - Happy Home (OG instrumental) (loop)
2pac - Heartz Of Men (instrumental)
2pac - Hell For A Hustler (instrumental)
2pac - Hennessey (Red Spyda Remix instrumental)
2pac - Hit Em Up 2 (loop)
2pac - Hit Em Up (unofficial instrumental) <-ripped from House Of Blues DVD so its legit, though never officially released
2pac - Holler If Ya Hear Me (Black Caesar instrumental)
2pac - Holler If Ya Hear Me (Broadway Mix instrumental)
2pac - Holler If Ya Hear Me (New York Stretch Mix instrumental)
2pac - Homeboyz (instrumental)
2pac - Homeboyz (remix instrumental)
2pac - I Get Around (remix instrumental)
2pac - I Wonder If Heaven Got A Ghetto (Soulpower Hip Hop instrumental)
2pac - If I Die Tonight (instrumental)
2pac - If My Homie Calls (instrumental)
2pac - In His Own Words (instrumental)
2pac - It Ain't Easy (instrumental +hook)
2pac - It Ain't Easy (instrumental)
2pac - Keep Ya Head Up (unofficial instrumental)
2pac - Killing Fields (instrumental)
2pac - Let Em Have It (instrumental)
2pac - Letter 2 My Unborn Child (instrumental)
2pac - Lost Souls (instrumental)
2pac - One Day At A Time (instrumental)
2pac - Pour Out A Little Liquor (Madukey instrumental)
2pac - So Many Tears (instrumental)
2pac - Street Life (instrumental)
2pac - Temptations (instrumental)
2pac - The Lunatic (instrumental)
2pac - They Don't Give A Fuck About Us (unofficial instrumental) - came in a "promo" but sounds like a looped remake since its different from the original track
2pac - Thug Nature (instrumental)
2pac - Toss It Up (instrumental)
2pac - Toss It Up (OG instrumental)
2pac - Trapped (instrumental)
2pac - Until The End Of Time (instrumental)
2pac - Whatz Ya Phone # (instrumental)
2pac - When We Ride On Our Enemies (OG instrumental) (loop)
2pac - Where I Will Be (instrumental)
2pac - Wonder Why They Call U Bitch (instrumental)
2pac & Big L - Deadly Combination (instrumental)
2pac & Bone Thugs-N-Harmony - Thug Luv (instrumental)
2pac & Keyshia Cole - Playa Cardz Right (instrumental)
2pac & Notorious B.I.G. - Runnin (Stone's Remix instrumental +hook)
2pac & Notorious B.I.G. - Runnin (Stone's Remix instrumental)
2pac & Snoop Dogg - 2 Of Amerikaz Most Wanted (instrumental)
2pac & Snoop Dogg - Wanted Dead Or Alive (instrumental)
2pac & The Outlawz - World Wide (instrumental)
2pac ft. 50 Cent - The Realest Killaz (instrumental)
2pac ft. Anthony Hamilton - Thugz Mansion (instrumental)
2pac ft. Ashanti, T.I. - Pac's Life (instrumental)
2pac ft. Big Syke - Loyal To The Game (DJ Quik Remix instrumental)
2pac ft. Bone Thugs-N-Harmony - Untouchable (club instrumental)
2pac ft. Bone Thugs-N-Harmony - Untouchable (LP instrumental)
2pac ft. Candy Hill - What'z Ya Phone Number (instrumental)
2pac ft. Daz, Tanya Herron - First 2 Bomb (remix instrumental)
2pac ft. Dr. Dre - California Love (LP instrumental)
2pac ft. Dr. Dre - California Love (remix instrumental)
2pac ft. Eminem - Insomniac (instrumental)
2pac ft. K-Ci & JoJo - How Do U Want It (instrumental)
2pac ft. K-Ci & JoJo - Thug N U Thug N Me (remix instrumental)
2pac ft. Lil Mo - Niggaz Nature (remix instrumental)
2pac ft. Nas - Thugz Mansion (acoustic instrumental)
2pac ft. Nate Dogg - Thugs Get Lonely Too (instrumental)
2pac ft. Notorious B.I.G. - Be The Realist (realstrumental dub)
2pac ft. Ron Isley - Po Nigga Blues (Scott Storch Remix instrumental)
2pac ft. Scarface - Smile (instrumental)
2pac ft. The Notorious B.I.G. - Runnin (Dying To Live) (instrumental)
2pac ft. The Outlawz - Baby Don't Cry (Keep Ya Head Up II) (instrumental)
2pac ft. The Outlawz - Immortal (instrumental) (arranged from master reel)
2pac ft. The Outlawz - U Can Be Touched (OG instrumental)
2pac ft. The Outlawz - U Can Be Touched (Still I Rise instrumental)
2pac ft. Thug Life - It Don't Stop (Instrumental)
2pac ft. Thug Life, Nate Dogg - How Long Will They Mourn Me (instrumental)
2pac ft. Trick Daddy - Still Ballin (instrumental)
2pac ft. Wallen - Letter 2 My Unborn (remix instrumental)
Above The Law ft. 2pac, Money B - Call It What U Want (instrumental)
Ashanti ft. Caddillac Tah - The Pledge (instrumental) - beat is the same as remix except longer so I included this
Ashanti, Ja Rule, Nas, 2pac - The Pledge Remix (instrumental)
Benzino ft. 2pac, Freddie Foxxx -Trying To Make It Through (instrumental)
Digital Underground - Same Song (Rapless Edit instrumental)
Digital Underground - Wassup Wit The Luv (instrumental)
E-40 ft. 2Pac, B-Legit - Million Dollar Spot (instrumental)
E-40 ft. 2pac, Mac Mall, Spice 1 - Dusted N Disgusted (instrumental)
Hussein Fatal - Everyday (instrumental) (2pac & Kadafi tribute)
Jon B. ft. 2pac - Are You Still Down (instrumental)
Jon B. ft. 2pac - Part 2 (instrumental)
N.I.N.A. ft. 2pac - Untouchable (Tha Row Remix instrumental)
Richie Rich ft. 2pac - Niggaz Done Changed (instrumental)
Scarface ft. Master P, 2pac - Homies And Thuggs (remix instrumental)
Swoop G ft. 2pac, 2scoops - World Don't Take Me Personally (instrumental)
The Outlawz ft. Geronimo Ji Jaga - In The Event Of My Demise (instrumental) (written by 2pac)
Thug Life - Cradle To The Grave (Madukey Mix instrumental)
Thug Life - Cradle To The Grave (Moe-Z instrumental)
Thug Life - Str8 Ballin (instrumental)
Young Lay ft. Ray Luv, Mac Mall, 2pac - Got 2 Survive (instrumental)
Yukmouth ft. The Outlawz - Still Ballin (instrumental) (2pac tribute)

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2pac - Out On Bail (OG instrumental)
2pac - Thug 4 Life (Jellyroll Remix instrumental)
2pac - Words 2 My First Born (Death Row Remix instrumental)
2pac ft. Keyshia Cole - Don't U Trust Me (Stereotypes Remix instrumental)
2pac ft. Ray Dog, Freddie Foxxx - Don't Fuck With A Killa (instrumental)

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2pac ft. Kadafi - Who Do U Believe In (instrumental)

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2pac - Never Call U Bitch Again (House OF Blues DVD instrumental)
2pac - Tattoo Tearz (House OF Blues DVD instrumental)
2pac - Troublesome '96 (House OF Blues DVD instrumental)
2pac ft. Nate Dogg - All Bout U (House OF Blues DVD instrumental)

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2pac ft. Big Daddy Kane - Wherever U R (loop)
2pac ft. Outlawz - Secretz Of War (loop)

DOWNLOAD - MF

DOWNLOAD - RS